Leading French director dies of Covid

Jean-Pierre Vincent, a close associate of Patrice Chéerau and his successor at the head of the Théâtre Nanterre-Amandiers, has died aged 78 of the Corinavirus.

Director of the Théâtre national de Strasbourg and of the Comédie-Française in Paris, he was an influential board member of the Avignon Festival. His son, Thomas Vincent, directed the stylish BBC-TV series Bodyguard.

 

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  • An interesting study was recently presented by Dr John Campbell based on this published peer reviewed paper.

    Morens et al 2008 Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness

    The Journal of Infectious Diseases, Volume 198, Issue 7, 1 October 2008, Pages 962–970.https://academic.oup.com/jid/article/

    Method

    Prior to the use of antibiotics 1918 –1919 “Spanish flu” (H1N1) pandemic, 675,000 excess US deaths (1.9 million on current population figures) Examined lung tissue sections Obtained during 58 autopsies.

    Reviewed pathologic and bacteriologic data from 109 published autopsy series that described 8,398 individual autopsy investigations.

    Results
    Uniformly exhibited severe changes indicative of bacterial pneumonia Bacteria, neutrophils, blood.

    Bacteriologic and histopathologic results clearly and consistently implicated secondary bacterial pneumonia caused by common upper respiratory tract bacteria in most influenza fatalities

    Many different bacterial strains. Blood culture data, 1,887 subjects. Positive results in 70.3% of cases, typically contained either pneumococci or streptococci.

    Conclusions
    The majority of deaths in the 1918–1919 influenza pandemic likely resulted directly from secondary bacterial pneumonia. Caused by common upper respiratory–tract bacteria Viral-bacterial co-pathogenesis

    Prevention, diagnosis, prophylaxis, and treatment of secondary bacterial pneumonia Stockpiling of antibiotics and bacterial vaccines Less substantial data from subsequent pandemics 1957 H2N2 Asian flu, 86,000 excess US deaths 1968 H3N2 Hong Kong flu, 56,300 excess US deaths

    Most deaths due to secondary bacterial infection. The extraordinary severity of the 1918 pandemic remains un- explained. Today we have pneumococcal vaccine and antibiotics.

    Dr John Campbell discusses the historic 1918 Flu pandemic publication here.

    https://www.youtube.com/watch?v=Oo53rojlp5Q

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